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Bismuth(III) deferiprone effectively inhibits growth of Desulfovibrio desulfuricans ATCC 27774
Ist Teil von
Biometals, 2016-04, Vol.29 (2), p.311-319
Ort / Verlag
Dordrecht: Springer Netherlands
Erscheinungsjahr
2016
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Sulfate-reducing bacteria have been implicated in inflammatory bowel diseases and ulcerative colitis in humans and there is an interest in inhibiting the growth of these sulfide-producing bacteria. This research explores the use of several chelators of bismuth to determine the most effective chelator to inhibit the growth of sulfate-reducing bacteria. For our studies,
Desulfovibrio desulfuricans
ATCC 27774 was grown with nitrate as the electron acceptor and chelated bismuth compounds were added to test for inhibition of growth. Varying levels of inhibition were attributed to bismuth chelated with subsalicylate or citrate but the most effective inhibition of growth by
D. desulfuricans
was with bismuth chelated by deferiprone, 3-hydroxy-1,2-dimethyl-4(1
H
)-pyridone. Growth of
D. desulfuricans
was inhibited by 10 μM bismuth as deferiprone:bismuth with either nitrate or sulfate respiration. Our studies indicate deferiprone:bismuth has bacteriostatic activity on
D. desulfuricans
because the inhibition can be reversed following exposure to 1 mM bismuth for 1 h at 32 °C. We suggest that deferiprone is an appropriate chelator for bismuth to control growth of sulfate-reducing bacteria because deferiprone is relatively nontoxic to animals, including humans, and has been used for many years to bind Fe(III) in the treatment of β-thalassemia.