Details

Autor(en) / Beteiligte

• Zhang, Lingyu
• Wang, Tingting
• Yang, Lei
• Liu, Cong
• Wang, Chungang
• Liu, Haiyan
• Wang, Y. Andrew
• Su, Zhongmin

Titel

General Route to Multifunctional Uniform Yolk/Mesoporous Silica Shell Nanocapsules: A Platform for Simultaneous Cancer-Targeted Imaging and Magnetically Guided Drug Delivery

Ist Teil von

• Chemistry : a European journal, 2012-09, Vol.18 (39), p.12512-12521

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2012

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Hollow mesoporous SiO2 (mSiO2) nanostructures with movable nanoparticles (NPs) as cores, so‐called yolk‐shell nanocapsules (NCs), have attracted great research interest. However, a highly efficient, simple and general way to produce yolk‐mSiO2 shell NCs with tunable functional cores and shell compositions is still a great challenge. A facile, general and reproducible strategy has been developed for fabricating discrete, monodisperse and highly uniform yolk‐shell NCs under mild conditions, composed of mSiO2 shells and diverse functional NP cores with different compositions and shapes. These NPs can be Fe3O4 NPs, gold nanorods (GNRs), and rare‐earth upconversion NRs, endowing the yolk‐mSiO2 shell NCs with magnetic, plasmonic, and upconversion fluorescent properties. In addition, multifunctional yolk‐shell NCs with tunable interior hollow spaces and mSiO2 shell thickness can be precisely controlled. More importantly, fluorescent‐magnetic‐biotargeting multifunctional polyethyleneimine (PEI)‐modified fluorescent Fe3O4@mSiO2 yolk‐shell nanobioprobes as an example for simultaneous targeted fluorescence imaging and magnetically guided drug delivery to liver cancer cells is also demonstrated. This synthetic approach can be easily extended to the fabrication of multifunctional yolk@mSiO2 shell nanostructures that encapsulate various functional movable NP cores, which construct a potential platform for the simultaneous targeted delivery of drug/gene/DNA/siRNA and bio‐imaging. Yolk‐shell nanocapsules: A simple, general, and reproducible strategy for fabricating the monodisperse and highly uniform amino‐functionalized yolk‐shell nanocapsules with fluorescent mesoporous SiO2 (fmSiO2) shells is reported to produce yolk‐fmSiO2 shell nanostructures that encapsulate the movable cores (see figure). Use of the Fe3O4@fmSiO2 yolk‐shell NCs in simultaneous fluorescence imaging and magnetically guided drug delivery of cancer cells is also demonstrated.