Details

Autor(en) / Beteiligte

• Chabaud, Laurent
• Raynal, Quentin
• Barre, Elvina
• Guillou, Catherine

Titel

Rhodium(III)-Catalyzed Synthesis of Aryl Spirocycles by Aromatic CH Activation/Intramolecular Heck-Type Reaction

Ist Teil von

• Advanced synthesis & catalysis, 2015-12, Vol.357 (18), p.3880-3884

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

Wiley InterScience Journals

Beschreibungen/Notizen

• The rhodium(III)‐catalyzed aromatic CH activation/intramolecular Heck‐type reaction has been studied to synthesize spirocyclic compounds, an important class of molecules in medicinal chemistry and natural product synthesis. This approach was efficient with a variety of substituted N‐methoxybenzamides tethered to different cyclic alkenes having a 5‐, 6‐ or 7‐membered ring. This practical method affords sterically hindered o‐substituted aryl spirocycles that are valuable compounds for further functionalization to access relevant building blocks.