Advanced healthcare materials, 2012-05, Vol.1 (3), p.342-347
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma
- Ist Teil von
- Advanced healthcare materials, 2012-05, Vol.1 (3), p.342-347
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2012
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA‐approved and targetable PEG‐based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell‐specific recognition of the Ag‐1‐PNPs‐Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2192-2640eISSN: 2192-2659DOI: 10.1002/adhm.201100047Titel-ID: cdi_proquest_miscellaneous_1800478111
- Format
- –
- Schlagworte
- Biotechnology, Cell Line, Tumor, Drug Carriers - chemistry, Entrapment, glioblastoma, Glioblastoma - drug therapy, Glioblastoma - pathology, Health care, Humans, Hydrophobic and Hydrophilic Interactions, Metal Nanoparticles - chemistry, Metal Nanoparticles - therapeutic use, Nanocapsules - chemistry, Nanocapsules - therapeutic use, Nanocapsules - ultrastructure, nanomedicine, Nanoparticles, Nanostructure, PEG-based polymer, Polyethylene Glycols - chemistry, Recognition, Silver, Silver - administration & dosage, silver nanoparticles, Treatment Outcome, uptake, Uptakes