Details

Autor(en) / Beteiligte

• Chen, Jie
• Jiao, Zi-xue
• Lin, Lin
• Guo, Zhao-pei
• Xu, Cai-na
• Li, Yan-hui
• Tian, Hua-yu
• Chen, Xue-si

Titel

Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment

Ist Teil von

• Chinese journal of polymer science, 2015-06, Vol.33 (6), p.830-837

Ort / Verlag

Beijing: Chinese Chemical Society and Institute of Chemistry, CAS

Erscheinungsjahr

2015

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Polyethylenimine-poly（L-lysine） （PEI-PLL） copolymer was synthesized via ring-opening polymerization of L-lysine N-carboxyanhydride （Lys（Z）-NCA） initiated by PEI. The complexation of PEI-PLL with siRNA was studied by particle size and zeta potential measurements. The flow cytometric analysis and confocal imaging showed its excellent intracellular trafficking ability. PEI-PLL displayed higher gene silencing efficiency and lower cytotoxicity than commercial PEI-25k in vitro. In the antitumor study, PEI-PLL was further combined with siVEGF and showed obviously tumor inhibition effect for the treatment of CT26 tumor model. Therefore, PEI-PLL is a promising siRNA carrier candidate for further antitumor treatment in vivo.