Details

Autor(en) / Beteiligte

• Atanasov, Georgi
• Hau, Hans-Michael
• Dietel, Corinna
• Benzing, Christian
• Krenzien, Felix
• Brandl, Andreas
• Englisch, Julianna P.
• Wiltberger, Georg
• Schierle, Katrin
• Robson, Simon C.
• Reutzel-Selke, Anja
• Jonas, Sven
• Pascher, Andreas
• Pratschke, Johann
• Schmelzle, Moritz

Titel

Prognostic significance of TIE2-expressing monocytes in hilar cholangiocarcinoma

Ist Teil von

• Journal of surgical oncology, 2016-07, Vol.114 (1), p.91-98

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background and Objectives Angiopoietins (Angs) play a pivotal role in angiogenesis and inflammation, and are associated with prognosis in malignancies. Monocyte express Ang‐receptor TIE2 and correlate with prognosis in cancer. We aimed to investigate the prognostic value of Angs and TIE2‐expressing monocytes (TEMs) in cholangiocarcinoma. Methods We analyzed surgically resected tumor specimens of hilar cholangiocarcinoma (n = 47) for distribution of Angs (Ang 1/Ang 2) and TEMs, as defined by co‐expression of CD14 and Ang receptor TIE2. Ang expression and abundance of TEMs were correlated with clinicopathologic characteristics, tumor recurrence and patients' survival. Results High Ang 1 expression correlated with reduced metastasis (P < 0.05). Patients characterized by invading Ang‐receptor bearing TEMs in tumor showed lower tumor recurrence (P < 0.05). Furthermore, TEMs in tumor and tumor invasive front correlated with increased survival (P < 0.05). TEMs in tumor invasive front were confirmed as independent prognosticator in multivariate survival analysis (P < 0.05). Conclusions High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TEMs defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Besides suggested functional links between Ang expression and recruitment of TEMs, our data have possible clinical implications as novel diagnostic tools. J. Surg. Oncol. 2016;114:91–98. © 2016 Wiley Periodicals, Inc.