Details

Autor(en) / Beteiligte

• Pan, Calvin Q
• Duan, Zhongping
• Dai, Erhei
• Zhang, Shuqin
• Han, Guorong
• Wang, Yuming
• Zhang, Huaihong
• Zou, Huaibin
• Zhu, Baoshen
• Zhao, Wenjing
• Jiang, Hongxiu

Titel

Tenofovir to Prevent Hepatitis B Transmission in Mothers with High Viral Load

Ist Teil von

• The New England journal of medicine, 2016-06, Vol.374 (24), p.2324-2334

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Prevention of mother-to-child transmission of hepatitis B virus remains a challenge in mothers with a viral load above 200,000 IU per milliliter. In this trial in China, tenofovir was assessed as a tool to decrease perinatal HBV transmission in pregnant women with a high viral load. Chronic hepatitis B virus (HBV) infection remains a serious threat to public health and is associated with cirrhosis and liver cancer. 1 , 2 Although long-term antiviral therapy can reduce the severity of cirrhosis and the incidence of liver cancer, the eradication of HBV is rare. 1 , 3 Thus, the prevention of HBV transmission is the most effective way to reduce the global burden of hepatitis B infection and liver cancer. 4 , 5 Pregnant mothers with chronic HBV infection can vertically transmit HBV to their infants, 6 – 8 and if untreated, chronic HBV infection will develop in 80 to 90% of infants born to mothers . . .