Molecular & cellular oncology, 2015-07, Vol.2 (3), p.e975035-e975035
2015
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Details
- Autor(en) / Beteiligte
- Titel
- p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
- Ist Teil von
- Molecular & cellular oncology, 2015-07, Vol.2 (3), p.e975035-e975035
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2015
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation on the underlying molecular mechanisms has revealed a multifaceted role for p62 in HER2-associated mammary tumorigenesis.