Details

Autor(en) / Beteiligte

• Park, G.-M
• Cho, Y.-R
• Lee, S.-W
• Yun, S.-C
• Gil, E.H
• Kim, D.W
• Kim, T.-S
• Kim, C.J
• Cho, J.S
• Park, M.-W
• Her, S.H
• Kim, Y.-H
• Yang, D.H
• Kang, J.-W
• Lim, T.-H
• Jung, C.H
• Koh, E.H
• Lee, W.J
• Kim, M.-S
• Lee, K.-U
• Kim, H.-K
• Choe, J
• Park, J.-Y

Titel

Family history of diabetes and the risk of subclinical atherosclerosis

Ist Teil von

• Diabetes & metabolism, 2016-06, Vol.42 (3), p.170-177

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Aim This study investigated the influence of a family history of diabetes on the risk of subclinical coronary atherosclerosis according to coronary computed tomography angiography (CCTA) in asymptomatic individuals. Methods A total of 6434 consecutive asymptomatic individuals with no prior history of coronary artery disease voluntarily underwent CCTA evaluation as part of a general health examination. Coronary atherosclerotic plaque and significant coronary artery stenosis (degree of stenosis ≥50%) on CCTA were assessed. Logistic regression analysis was used to determine the association between a family history of diabetes and atherosclerotic plaque or significant coronary artery stenosis according to the degree of diabetes (normal, prediabetic and diabetic). Results Mean age of study participants was 53.7 ± 7.6 years, and 4694 (73.0%) were male. A total of 1593 (24.8%) participants had a family history of diabetes in a first-degree relative. Among the study participants, 1115 (17.3%), 3122 (48.5%) and 2197 (34.1%) were categorized as diabetic, prediabetic and normal, respectively. In diabetic participants, after stepwise adjustments for clinical and laboratory variables, a family history of diabetes was significantly associated with non-calcified plaque ( P < 0.05 for all), but did not appear to be associated with either calcified or mixed plaques or with significant coronary artery stenosis ( P > 0.05 for all). In prediabetic and normal participants, a family history of diabetes was not associated with either atherosclerotic plaque or significant coronary artery stenosis ( P > 0.05 for all). Conclusion In asymptomatic diabetic individuals, a family history of diabetes is consistently associated with non-calcified coronary plaque after adjusting for risk factors.