Details

Autor(en) / Beteiligte

• Lorente, Leonardo
• Martín, María M
• Ferreres, José
• Solé-Violán, Jordi
• Labarta, Lorenzo
• Díaz, César
• Jiménez, Alejandro
• Borreguero-León, Juan M

Titel

Serum caspase-3 levels are associated with early mortality in severe septic patients

Ist Teil von

• Journal of critical care, 2016-08, Vol.34, p.103-106

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective Higher caspase-3 active have been found in lymphocytes of septic patients than of healthy controls. However, an association between serum caspase-3 levels at moment of severe sepsis diagnosis and mortality in septic patients has not been previously demonstrated, and this was the main objective of the present study. Methods Observational study of 216 patients with severe sepsis in six Spanish Intensive Care Units. We collected serum samples at moment of severe sepsis diagnosis to determine levels of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18. End point was 30-day mortality. Results We found higher serum caspase-3 levels ( P < .001) and CCCK-18 ( P = .001) in non-survivors (n = 76) than in survivors (n = 140). Multiple binary logistic regression analysis showed that serum caspase-3 levels > 0.25 ng/mL was associated with 30-day mortality (Odds ratio = 6.51; 95% CI = 3.32–12.77; P < .001). Receiver operating characteristic analysis showed that the area under the curve to predict 30-day morality for serum caspase-3 levels was 0.73 (95% CI = 0.67–0.79; P < .001). Conclusions The major novel findings of our study were that there is an association between serum caspase-3 levels at moment of severe sepsis diagnosis and mortality in septic patients, and that serum caspase-3 levels could be used as prognostic biomarker; and further studies are need to corroborate those findings.