Details

Autor(en) / Beteiligte

• Solé-Navais, Pol
• Cavallé-Busquets, Pere
• Fernandez-Ballart, Joan D.
• Murphy, Michelle M.

Titel

Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development

Ist Teil von

• Biochimie, 2016-07, Vol.126, p.91-96

Ort / Verlag

France: Elsevier B.V

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Periconception supplementation with folic acid is recommended until 12 gestational weeks to prevent neural tube defects. Doses of folic acid contained in supplements and timing and length of use during pregnancy vary. The effects of status in periconception and pregnancy folate, cobalamin, betaine and their interactions on one carbon metabolism (1C), as well as the global effect of 1C on foetal growth and pregnancy outcome, are reviewed. Results from prospective studies are reviewed. Cessation of folic acid supplement use after the first trimester is associated with a sharp drop in plasma folate status and enhanced conversion of betaine to dimethylglycine. Dimethylglycine production is also higher in mothers with low folate status than in those with normal-high folate status. The effects of high doses of folic acid on one carbon metabolism in mothers with low early pregnancy cobalamin status and on foetal growth are also reviewed. Several studies report that moderately elevated early pregnancy fasting plasma total homocysteine (tHcy) is inversely associated with birth weight and a predictor of intrauterine growth retardation. There is also evidence for increased risk of preterm birth when maternal folate status is low. •Interactions between 1C metabolism nutrients during pregnancy affect homocysteine metabolism•Interactions between maternal folate and B12 status affect pregnancy outcome.•Low pregnancy B12 is associated with increased probability of gestational diabetes•Low pregnancy B12 affects insulin resistance & adiposity in the offspring•High pregnancy folate affects insulin resistance & adiposity in the offspring in some studies•Elevated early-mid pregnancy tHcy is inversely associated with birth weight