Details

Autor(en) / Beteiligte

• Doi, Adriana M
• Roycroft, Joseph H
• Herbert, Ronald A
• Haseman, Joseph K
• Hailey, James R
• Chou, Billy J
• Dill, Jeffrey A
• Grumbein, Sondra L
• Miller, Rodney A
• Renne, Roger A
• Bucher, John R

Titel

Inhalation toxicology and carcinogenesis studies of propylene glycol mono- t-butyl ether in rats and mice

Ist Teil von

• Toxicology (Amsterdam), 2004-06, Vol.199 (1), p.1-22

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Propylene glycol mono- t-butyl ether (PGMBE) is used as a solvent in a variety of commercial applications. Male and female F344/N rats and B6C3F 1 mice were exposed to PGMBE by whole-body inhalation for 2 or 14 weeks (0, 75, 150, 300, 600, or 1200 ppm) or 2 years (0, 75, 300, or 1200 ppm); male NBR rats were exposed for 2 weeks. The kidney and the liver were targets of PGMBE toxicity in rats. Renal lesions suggestive of α 2u-globulin nephropathy were observed in male F344/N, in the 2 and 14-week studies, no kidney lesions were seen in NBR rats. In the 2-year study, male rats displayed exposure-related nonneoplastic lesions in the kidney, and may have shown marginal increases in tubular neoplasms. In the liver, the incidences of hepatocellular adenomas occurred with a positive trend in male rats, and may have been related to PGMBE exposure. In mice of both sexes, the major target of PGMBE toxicity was the liver. In the 2-week study, liver weights and in the 14-week study, liver weights and the incidences of centrilobular hypertrophy were increased. In the 2-year study, the incidences of exposure-related hepatocellular adenoma, adenoma or carcinoma combined, and hepatoblastoma occurred with a positive trend, and were significantly increased in 1200 ppm groups. In summary, exposure to PGMBE resulted in nonneoplastic lesions of the kidney characteristic of α 2u-globulin nephropathy, and may have increased renal tubular neoplasms in male rats. Exposure to PGMBE also produced increases in hepatic tumors in male and female mice.