Details

Autor(en) / Beteiligte

• Cuervo, Guillermo
• Gasch, Oriol
• Shaw, Evelyn
• Camoez, Mariana
• Domínguez, María Ángeles
• Padilla, Belén
• Pintado, Vicente
• Almirante, Benito
• Lepe, José A
• López-Medrano, Francisco
• Ruiz de Gopegui, Enrique
• Martínez, José A
• Montejo, José Miguel
• Perez-Nadales, Elena
• Arnáiz, Ana
• Goenaga, Miguel Ángel
• Benito, Natividad
• Horcajada, Juan Pablo
• Rodríguez-Baño, Jesús
• Pujol, Miquel

Titel

Clinical characteristics, treatment and outcomes of MRSA bacteraemia in the elderly

Ist Teil von

• The Journal of infection, 2016-03, Vol.72 (3), p.309-316

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Objectives To compare clinical and microbiological characteristics, treatment and outcomes of MRSA bacteraemia among elderly and younger patients. Material and methods Prospective study conducted at 21 Spanish hospitals including patients with MRSA bacteraemia diagnosed between June/2008 and December/2009. Episodes diagnosed in patients aged 75 or more years old (≥75) were compared with the rest of them (<75). Results Out of 579 episodes of MRSA bacteraemia, 231 (39.9%) occurred in patients ≥75. Comorbidity was significantly higher in older patients (Charlson score ≥4: 52.8 vs. 44%; p = .037) as was the severity of the underlying disease (McCabe ≥1: 61.9 vs. 43.4%; p < .001). In this group the acquisition was more frequently health-care related (43.3 vs. 33.9%, p = .023), mostly from long-term care centers (12.1 vs. 3.7%, p < .001). An unknown focus was more frequent among ≥75 (19.9 vs. 13.8%; p = .050) while severity at presentation was similar between groups (Pitt score ≥3: 31.2 vs. 27.6%; p = .352). The prevalence of vancomycin resistant isolates was similar between groups, as was the appropriateness of empirical antibiotic therapy. Early (EM) and overall mortality (OM) were significantly more frequent in the ≥75 group (EM: 12.1 vs. 6%; p = .010 OM: 42.9 vs. 23%; p < .001). In multivariate analysis age ≥75 was an independent risk factor for overall mortality (aOR: 2.47, CI: 1.63–3.74; p < .001). Conclusion MRSA bacteraemia was frequent in patients aged ≥75 of our cohort. This group had higher comorbidity rates and the source of infection was more likely to be unknown. Although no differences were seen in severity or adequacy of empiric therapy, elderly patients showed a higher overall mortality.