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Evaluation of Crude Extract of Melia azedarach Linn. Against Attenuated Amphotericin B Resistant Leishmania tropica Strain
Ist Teil von
Journal of basic and applied sciences, 2015-12, Vol.11, p.314-317
Ort / Verlag
Karachi: AsiaNet Pakistan (Pvt) Ltd
Erscheinungsjahr
2015
Link zum Volltext
Beschreibungen/Notizen
Cutaneous leishmaniasis is still a big health problem around the world and drug resistance has emerged as a major problem in treatment. The purpose of the study was to generate Amphotericin B resistant strainand evaluate the crude extract of Melia azedarach against wild and lab generated resistant strain of Leishmania tropica. The result obtained revealed that the continuous increase of drug pressure for 60 days cause resistance in L. tropica by 09 fold compared to wild type. The LC50 value recorded for wild and resistant type strain was 0.024 and 0.224µg/ml, respectively against Amp B drug. The antileishmanial activity of crude extract against wild and resistant type strain was 0.57 and 123.3 µg/ml for green fruit and 1220.8 and 4010.1µg/ml for ripe fruit, respectively. A significant difference (P