Details

Autor(en) / Beteiligte

• Morand, Grégoire B.
• Fellmann, Jonas
• Laske, Roman D.
• Weisert, Jan U.
• Soltermann, Alex
• Zbinden, Reinhard
• Probst, Rudolf
• Huber, Gerhard F.

Titel

Detection of Helicobacter pylori in patients with head and neck cancer: Results from a prospective comparative study combining serology, polymerase chain reaction, and rapid urease test

Ist Teil von

• Head & neck, 2016-05, Vol.38 (5), p.769-774

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background The purpose of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori (H. pylori) in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma (HNSCC). Methods Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in patients with head and neck cancer (N = 56) and cancer‐free controls (N = 90). Comparison between groups was done using logistic regression analysis. Results Rates of positive serology and rapid urease test did not differ between the 2 groups in logistic regression analysis (p = .677 and p = .633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (p < .001 and p = .040, respectively). Using qPCR, no biopsy showed the presence of H. pylori. Conclusion This study challenges the concept that H. pylori may be a risk factor for HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 769–774, 2016