Details

Autor(en) / Beteiligte

• Thomasi, Sérgio Scherrer
• Ladeira, Cecília
• Ferreira, Douglas
• da Fontoura Sprenger, Ricardo
• Badino, Alberto Colli
• Ferreira, Antonio Gilberto
• Venâncio, Tiago

Titel

Identification of Two New Phosphorylated Polyketides from a Brazilian Streptomyces sp. Through the Use of LC-SPE/NMR

Ist Teil von

• Helvetica chimica acta, 2016-04, Vol.99 (4), p.281-285

Ort / Verlag

Zürich: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Two new polyketide phosphate monoesters, phosdiecin A (1) and phosdiecin B (2), were isolated from a culture of the marine Streptomyces sp. SS99BA‐2 using the hyphenated technology LC–SPE/NMR. The compounds showed to be new representatives of an important class of antitumor antibiotic metabolites known as fostriecins. Their structures, including relative configuration attribution, were fully elucidated through extensive analyses of NMR and MALDI‐TOF/TOF HR‐MS data. Herein, the application of this system to isolate and identify the new compounds is described.