Details

Autor(en) / Beteiligte

• Ubukata, Masamitsu
• Takei, Takashi
• Nitta, Kosaku

Titel

Estimation of the 24-h urinary protein excretion based on the estimated urinary creatinine output

Ist Teil von

• Clinical and experimental nephrology, 2016-06, Vol.20 (3), p.456-461

Ort / Verlag

Tokyo: Springer Japan

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The urinary protein/creatinine ratio [Up/Ucr (g/gCr)] has been used in the clinical management of patients with chronic kidney disease (CKD). However, a discrepancy is often noted between the Up/Ucr and 24-h urinary protein excretion [24hUp (g/day)] in patients with extremes of muscle mass. We examined devised a method for precise estimation of the 24-h urinary protein excretion (E-24hUp) based on estimation of 24-h urinary creatinine output (E-24hCr). Methods Three parameters, spot Up/Ucr, 24hUP and E-24hUp (=Up/Ucr × E-24hCr), were determined in 116 adult patients with CKD. The correlations among the groups were analyzed. Results There was a significant correlation between the Up/Ucr and 24hUp ( p  < 0.001). We divided the patients into three groups according to the 24hUp; the low urinary protein group (<1.0 g/day), the intermediate urinary protein group (1.0–3.5 g/day), and the high urinary protein group (>3.5 g/day). There was a significant correlation between the Up/Ucr and 24hUp in the low ( p  = 0.04) and high urinary protein ( p  = 0.01) groups, whereas the correlation coefficient was lower in the intermediate urinary protein ( p  = 0.07) group. Thus, we found a significant correlation between 24hUp and E-24hUp in the study population overall ( p  < 0.001), in the low ( p  = 0.01), in the intermediate ( p  < 0.001), and in the high urinary protein group ( p  < 0.001). Conclusion We conclude that a poor correlation exists between the Up/Ucr and 24hUp in patients with intermediate urinary protein excretion levels. The recommended parameter for monitoring proteinuria in such patients may be the E-24hUp, which is calculated using the E-24hCr.