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Estimation of the 24-h urinary protein excretion based on the estimated urinary creatinine output
Ist Teil von
Clinical and experimental nephrology, 2016-06, Vol.20 (3), p.456-461
Ort / Verlag
Tokyo: Springer Japan
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
Background
The urinary protein/creatinine ratio [Up/Ucr (g/gCr)] has been used in the clinical management of patients with chronic kidney disease (CKD). However, a discrepancy is often noted between the Up/Ucr and 24-h urinary protein excretion [24hUp (g/day)] in patients with extremes of muscle mass. We examined devised a method for precise estimation of the 24-h urinary protein excretion (E-24hUp) based on estimation of 24-h urinary creatinine output (E-24hCr).
Methods
Three parameters, spot Up/Ucr, 24hUP and E-24hUp (=Up/Ucr × E-24hCr), were determined in 116 adult patients with CKD. The correlations among the groups were analyzed.
Results
There was a significant correlation between the Up/Ucr and 24hUp (
p
< 0.001). We divided the patients into three groups according to the 24hUp; the low urinary protein group (<1.0 g/day), the intermediate urinary protein group (1.0–3.5 g/day), and the high urinary protein group (>3.5 g/day). There was a significant correlation between the Up/Ucr and 24hUp in the low (
p
= 0.04) and high urinary protein (
p
= 0.01) groups, whereas the correlation coefficient was lower in the intermediate urinary protein (
p
= 0.07) group. Thus, we found a significant correlation between 24hUp and E-24hUp in the study population overall (
p
< 0.001), in the low (
p
= 0.01), in the intermediate (
p
< 0.001), and in the high urinary protein group (
p
< 0.001).
Conclusion
We conclude that a poor correlation exists between the Up/Ucr and 24hUp in patients with intermediate urinary protein excretion levels. The recommended parameter for monitoring proteinuria in such patients may be the E-24hUp, which is calculated using the E-24hCr.