Details

Autor(en) / Beteiligte

• Pêgo, Sabina Pena B., PhD
• de Faria, Paulo Rogério, PhD
• Santos, Luis Antônio N., PhD
• Coletta, Ricardo D., PhD
• de Aquino, Sibele Nascimento, PhD
• Martelli-Júnior, Hercílio, PhD

Titel

Ultrastructural evaluation of gingival connective tissue in hereditary gingival fibromatosis

Ist Teil von

• Oral surgery, oral medicine, oral pathology and oral radiology, 2016-07, Vol.122 (1), p.81-88.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective To describe the ultrastructural features of hereditary gingival fibromatosis (HGF)-affected family members and compare these microscopic findings with normal gingival tissue (NG). Study Design Gingival tissue from 9 HGF patients belonging to five unrelated families was evaluated by transmission electron microscopy. Nine NG tissue samples were used for comparison. Results Areas containing collagen fibrils forming loops and folds were observed in both groups, whereas oxytalan fibres were frequently identified in the HGF group. Collagen fibrils’ diameter and the interfibrillar space among them were more uniform in the NG group than the HGF group. Fibroblasts were the most common cells found in both the HGF and NG groups and exhibited enlarged rough endoplasmic reticulum, mitochondria with well-preserved crests, conspicuous nucleoli and euchromatic chromatin. Other cells, such as mast cells, plasma cells and macrophages, were also observed. Conclusion HGF tissues had very similar ultrastructural characteristics to those of the NG. Oxytalan fibres were observed more frequently in HGF samples than NG samples. Other studies involving different HGF-harbouring families should be performed to better understand the pathogenesis of this hereditary condition.