Details

Autor(en) / Beteiligte

• Bag, Partha Pratim
• Wang, Dong
• Chen, Zhuo
• Cao, Rong

Titel

Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier

Ist Teil von

• Chemical communications (Cambridge, England), 2016-01, Vol.52 (18), p.3669-3672

Ort / Verlag

England

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• A robust, highly water stable (up to 3 weeks), microporous MOF, [Zn8(O)2(CDDB)6(DMF)4(H2O)] {where CDDB = 4,4'-(9-H carbazole-3,6-diyl)dibenzoic acid}, was synthesized based on an open N-H site by a solvothermal process and exhibited an outstanding loading capacity (around 53.3 wt%) and satisfactory release capability (64.9% and 81.9%) for 5-fluorouracil, constituting a negligible cytotoxicity effect.