Details

Autor(en) / Beteiligte

• Aguiar, Elroy J., PhD
• Morgan, Philip J., PhD
• Collins, Clare E., PhD
• Plotnikoff, Ronald C., PhD
• Young, Myles D., PhD
• Callister, Robin, PhD

Titel

Efficacy of the Type 2 Diabetes Prevention Using LifeStyle Education Program RCT

Ist Teil von

• American journal of preventive medicine, 2016-03, Vol.50 (3), p.353-364

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Introduction Self-administered lifestyle interventions have been suggested as an alternative to face-to-face delivery modes, although their efficacy remains uncertain. The aim of this study was to evaluate the efficacy of the Type 2 diabetes mellitus Prevention Using LifeStyle Education (PULSE) Program, a self-administered and gender-tailored lifestyle intervention for men at high risk for developing Type 2 diabetes mellitus. Design/setting A 6-month, assessor-blinded, parallel-group RCT was conducted at the University of Newcastle, Australia in 2012−2013. Participants Men (aged 18−65 years, BMI 25−40 kg/m2 , high risk for developing Type 2 diabetes mellitus) were stratified by age (<50 and >50 years) and BMI category (25.0−29.9, 30.0−35.9, and 35.0−40 kg/m2 ) and individually randomized (1:1 ratio) to the intervention ( n =53) or waitlist control groups ( n =48). Intervention The intervention group received the PULSE Program, which contained print and video resources on weight loss (Self-Help, Exercise and Diet using Internet Technology [SHED-IT] Weight Loss Program), diet modification, and exercise for Type 2 diabetes mellitus prevention. The waitlist control group received no information until 6 months. Main outcome measures Data were collected from September 2012 to September 2013 and analyzed in 2014−2015. Linear mixed models (intention-to-treat) were used to determine group X time interactions (differences between groups in changes over time) at 6 months for the primary outcome (weight), glycated hemoglobin, and several secondary outcomes (significance level, p <0.05). Results Differences between groups in mean changes from baseline to 6 months (group × time interaction) favored the intervention over control group for weight loss (−5.50 kg, 95% CI=−7.40 kg, −3.61 kg, p <0.001, Cohen’s d =1.15), glycated hemoglobin (−0.2%, 95% CI=−0.3%, −0.1%, p =0.002, d =0.64), and BMI, waist circumference, body fat percentage, aerobic fitness, and lower body muscular fitness (all p <0.05). No group × time effects were observed for fasting plasma glucose, upper body muscular fitness, physical activity, or energy intake. Conclusions The PULSE Program improved several Type 2 diabetes mellitus risk factors in men, including weight and glycated hemoglobin. These findings provide evidence for a self-administered and gender-tailored lifestyle intervention, which has potential for dissemination in community settings.