Details

Autor(en) / Beteiligte

• Wang, Zi-Ran
• Li, Yu-Xin
• Lei, Hong-Yan
• Yang, Dai-Qun
• Wang, Li-Quan
• Luo, Ming-Yu

Titel

Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats

Ist Teil von

• Asian Pacific journal of tropical medicine, 2016-03, Vol.9 (3), p.269-272

Ort / Verlag

India: Elsevier B.V

Erscheinungsjahr

2016

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Objective:To observe the effect of nuclear transcription factor- κB(NF- κB) on cerebral edema in rats with traumatic brain injury(TBI).Methods:Male SD rau with fluid percussion injury(FPI) were selected.After separation and culture,rats’ astrocytes all suffered FPL The expression of NF-κB and the water content were detected at the animal and cellular levels,while the activity of NOX was evaluated at the cellular level.Results:According to the results,the positive expression of NF-κB and expression of mRNA were significantly increased and the water content was increased for rats after TBI.while NF-κB inhibitor BAY 11-7082 could significantly reduce the effect of TBI.1 and 3h after FPI of astrocytes,the activation of NFkB was incrcased and BAY 11-7082 could significantly improve the injury-induced swelling of astrocytes.After the injury of astrocytes,the activity of NOX was also increased,while BAY11-7082 could reduce the activity of NOX.Conclusions:The results show that the activation of NF- κB in astrocytes is a key factor in the process of cerebral edema after TBI of rats.