Details

Autor(en) / Beteiligte

• Rezk, Noha A.
• Sabbah, Norhan A.
• Saad, Mohamed S.S.

Titel

Role of MicroRNA 126 in screening, diagnosis, and prognosis of diabetic patients in Egypt

Ist Teil von

• IUBMB life, 2016-06, Vol.68 (6), p.452-458

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2016

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• MicroRNAs (miRNAs), family of non‐coding small RNAs, play a vital role in the regulation of blood glucose level. We aimed to investigate the relation of serum miRNA‐126 expression with impaired glucose tolerance as well as type 2 diabetes mellitus (T2DM) patients with and without complications. One hundred healthy controls, eighty‐six patients with IGT, and one hundred patients with T2DM were recruited in this study. Serum miRNA‐126 expression was assessed by quantitative real‐time polymerase chain reaction. We found a significant decrease of serum miRNA‐126 expression between IGT patients as well as diabetic patients when both compared with controls and between diabetic patients compared to IGT patients. A significant decrease of serum miRNA‐126 expression was detected in diabetic patients with complications compared to those without evident complications especially those with diabetic macrovascular complications and diabetic retinopathy. Serum microRNA‐126 expression could be a good marker for diagnosis of IGT and T2DM as well as for monitoring the outcomes of such disease. © 2016 IUBMB Life, 68(6):452–458, 2016