Nature (London), 2016-05, Vol.533 (7603), p.333-337
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Reproducible pharmacogenomic profiling of cancer cell line panels
- Ist Teil von
- Nature (London), 2016-05, Vol.533 (7603), p.333-337
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the reproducibility of results. Here we consider two previously published screens, plus a later critique of these studies. Using independent data, we show that consistency is achievable, and provide a systematic description of the best laboratory and analysis practices for future studies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/nature17987Titel-ID: cdi_proquest_miscellaneous_1790463236
- Format
- –
- Schlagworte
- Antineoplastic Agents - pharmacology, Biomarkers, Cancer, Cell Line, Tumor, Cell Survival - drug effects, Cells, Deoxyribonucleic acid, DNA, Drug Screening Assays, Antitumor - methods, Drug Screening Assays, Antitumor - standards, Genetic Markers - genetics, Genome, Human - genetics, Genomics, Humans, Neoplasms - genetics, Neoplasms - pathology, Pharmacology, Quality Control, Reproducibility of Results