Details

Autor(en) / Beteiligte

• GOILA, Ritu
• KUMAR, Felix
• BANERJEA, Akhil C

Titel

MIP-1α promoter polymorphism in humans and monkeys : identification of two polymorphic regions characterized by the insertion of unique sequences in monkeys

Ist Teil von

• AIDS (London), 2001-05, Vol.15 (8), p.1065-1067

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2001

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In summary, we have, for the first time, identified a new kind of mutations (insertions) in the chemokine MIP-1 alpha gene promoter, both in monkeys and humans, the product of which is a chemokine that is known to inhibit the infection of R5 viruses. This insertion of sequences has the potential to create new or modify existing transcription factor binding sites. It was remarkable that the two polymorphic regions that were observed in langur and rhesus monkeys were not found in baboons. Common mutations in some humans at position -126 and monkeys strongly suggests that similar selective pressures must have acted on this gene. These observations raise interesting evolutionary questions and may also help understand why different species of monkeys produce widely varying outcomes to the disease when infected with HIV-1, HIV-2 or SIV.