Details

Autor(en) / Beteiligte

• Timiri, Ajay Kumar
• Sinha, Barij Nayan
• Jayaprakash, Venkatesan

Titel

Progress and prospects on DENV protease inhibitors

Ist Teil von

• European journal of medicinal chemistry, 2016-07, Vol.117, p.125-143

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• New treatments are desperately required to combat increasing rate of dengue fever cases reported in tropical and sub-tropical parts of the world. Among the ten proteins (structural and non-structural) encoded by dengue viral genome, NS2B–NS3 protease is an ideal target for drug discovery. It is responsible for the processing of poly protein that is required for genome replication of the virus. Moreover, inhibitors designed against proteases were found successful in Human Immuno-deficiency Virus (HIV) and Hepatitis C Virus (HCV). Complete molecular mechanism and a survey of inhibitors reported against dengue protease will be helpful in designing effective and potent inhibitors. This review provides an insight on molecular mechanism of dengue virus protease and covers up-to-date information on different inhibitors reported against dengue proteases with medicinal chemistry perspective. [Display omitted] •Proteolytic mechanism of DENV protease at molecular level.•Update of peptide inhibitors reported against DENV protease.•Peptide conjugates reported against DENV protease.•Small organic molecule inhibitors reported against DENV protease.