Constant B-cell lymphocytosis since early age in a patient with CARD11 mutation: A 20-year follow-up
2016
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- Autor(en) / Beteiligte
- Titel
- Constant B-cell lymphocytosis since early age in a patient with CARD11 mutation: A 20-year follow-up
- Ist Teil von
- Clinical immunology (Orlando, Fla.), 2016-04, Vol.165, p.19-20
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Lymphocytosis in gain of function (GOF) CARD11 mutation is not always detectable at early age. • Lymphocytosis diminishes towards adulthood. • Lack of NKT cells may play a role in Epstein Barr viremia in GOF CARD11 mutation. • TCRαβ + CD4–CD8-double-negative T-cells are elevated in GOF CARD11 mutation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1521-6616eISSN: 1521-7035DOI: 10.1016/j.clim.2016.02.002Titel-ID: cdi_proquest_miscellaneous_1787982766
- Format
- –
- Schlagworte
- Adult, Age Factors, Allergy and Immunology, B-Lymphocytes - pathology, CARD Signaling Adaptor Proteins - genetics, EBV, Female, Follow-Up Studies, Guanylate Cyclase - genetics, Humans, Immunodeficiency, Longitudinal Studies, Lymphocytosis, Lymphocytosis - genetics, Lymphocytosis - physiopathology, Mutation, Young Adult