Details

Autor(en) / Beteiligte

• Adamek, Mikołaj
• Rakus, Krzysztof L
• Brogden, Graham
• Matras, Marek
• Chyb, Jarosław
• Hirono, Ikuo
• Kondo, Hidehiro
• Aoki, Takashi
• Irnazarow, Ilgiz
• Steinhagen, Dieter

Titel

Interaction between type I interferon and Cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio

Ist Teil von

• Diseases of aquatic organisms, 2014-09, Vol.111 (2), p.107-118

Ort / Verlag

Germany

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.