Details

Autor(en) / Beteiligte

• Lajunen, T K
• Jaakkola, J J K
• Jaakkola, M S

Titel

Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma

Ist Teil von

• Genes and immunity, 2016-04, Vol.17 (3), p.193-198

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2016

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Interleukin 6 (IL6) is an inflammatory cytokine that has been suggested to have an important role in the pathogenesis of asthma. IL6 single-nucleotide polymorphisms (SNPs) have been associated with levels of IL6, and with childhood and prevalent adult asthma. A recent study also suggested that IL6 SNPs associate especially with atopic asthma. However, association of IL6 SNPs with adult-onset asthma has not been studied. In a population-based study of 467 incident adult-onset asthma cases and 613 disease-free controls from South Finland, we analyzed association of 6 tagging SNPs of the IL6 locus with the risk of adult-onset asthma and with atopy. Asthma was clinically diagnosed, and atopy was defined based on Phadiatop test. IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09–1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12–1.90). This is the first study to show an association of IL6 with adult-onset asthma, and especially with atopic adult-onset asthma.