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G protein-coupled receptors as promising cancer targets
Cancer letters, 2016-07, Vol.376 (2), p.226-239
2016

Details

Autor(en) / Beteiligte
Titel
G protein-coupled receptors as promising cancer targets
Ist Teil von
  • Cancer letters, 2016-07, Vol.376 (2), p.226-239
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Highlights • GPCR dysregulation can cause cancer, but the role of GPCRs in carcinogenesis has been largely ignored. • The latest developments suggest that GPCRs are among the most useful targets against diverse malignant cancers. • The selective ligands targeting GPCRs may provide novel and effective cancer therapeutics and indeed some anticancer compounds targeting GPCRs have entered clinical trials.
Sprache
Englisch
Identifikatoren
ISSN: 0304-3835
eISSN: 1872-7980
DOI: 10.1016/j.canlet.2016.03.031
Titel-ID: cdi_proquest_miscellaneous_1787762876
Format
–
Schlagworte
Activation, Alzheimer's disease, Angiogenesis, Animals, Antineoplastic Agents - therapeutic use, Breast cancer, Cancer, Cell growth, Chemical bonds, Drug Design, Genetic Predisposition to Disease, GPCR, GPR30, Hematology, Oncology and Palliative Medicine, Humans, Ligands, Lung cancer, Melanoma, Metastasis, Molecular Targeted Therapy, Mutation, Neoplasms - drug therapy, Neoplasms - genetics, Neoplasms - metabolism, Neoplasms - pathology, Nervous system, Ovarian cancer, Phenotype, Prostate cancer, Proteins, Receptor Cross-Talk, Receptors, G-Protein-Coupled - drug effects, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, Signal Transduction - drug effects, Skin cancer, Thyroid gland

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