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Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Ist Teil von
The New England journal of medicine, 2016-05, Vol.374 (18), p.1711-1722
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
In this trial, patients with out-of-hospital cardiac arrest received amiodarone, lidocaine, or placebo for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia. There were no significant between-group differences in survival to hospital discharge.
Out-of-hospital cardiac arrest is responsible for more than 300,000 deaths each year in North America.
1
Many out-of-hospital cardiac arrests are attributable to ventricular fibrillation or pulseless ventricular tachycardia. Although ventricular fibrillation or pulseless ventricular tachycardia is regarded as the most treatable presentation of out-of-hospital cardiac arrest because of its responsiveness to shock,
2
most defibrillation attempts do not result in sustained return of spontaneous circulation.
3
Ventricular fibrillation or pulseless ventricular tachycardia commonly persists or recurs after shock, and there is a significant inverse relationship between the duration of ventricular fibrillation or pulseless ventricular tachycardia, or the frequency of acute recurrences, and . . .