Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Ruthenium(II)-Catalyzed CH Activation with Isocyanates: A Versatile Route to Phthalimides
Ist Teil von
Chemistry : a European journal, 2014-10, Vol.20 (43), p.13932-13936
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
A cationic ruthenium(II)‐complex was utilized in the efficient synthesis of phthalimide derivatives by CH activation with synthetically useful amides. The reaction proceeded through a mechanistically unique insertion of a cycloruthenated species into a CHet multiple bond of isocyanate. The novel method also proved applicable for the synthesis of heteroaromatic unsymmetric diamides as well as a potent COX‐2 enzyme inhibitor.
A convenient route to phthalimide: A convergent method for the ruthenium(II)‐catalyzed imidation of easily accessible benzamides by CH functionalization was developed (see scheme). The methodology was successfully applied to the preparation of synthetically challenging unsymmetrical heteroaromatic diamides and proved amenable to a step‐economic synthesis of a potent COX‐2 enzyme inhibitor.