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Competition and Cooperation in Dynamic Replication Networks
Ist Teil von
Chemistry : a European journal, 2015-01, Vol.21 (2), p.648-654
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
The simultaneous replication of six coiled‐coil peptide mutants by reversible thiol–thioester exchange reactions is described. Experimental analysis of the time dependent evolution of networks formed by the peptides under different conditions reveals a complex web of molecular interactions and consequent mutant replication, governed by competition for resources and by autocatalytic and/or cross‐catalytic template‐assisted reactions. A kinetic model, first of its kind, is then introduced, allowing simulation of varied network behaviour as a consequence of changing competition and cooperation scenarios. We suggest that by clarifying the kinetic description of these relatively complex dynamic networks, both at early stages of the reaction far from equilibrium and at later stages approaching equilibrium, one lays the foundation for studying dynamic networks out‐of‐equilibrium in the near future.
On the web: The evolution of peptide replication within dynamic networks is governed by competition for resources and by autocatalytic and cross‐catalytic template‐assisted reactions. Experiments under various conditions and a new kinetic model reveal the network behaviour as a consequence of changing competition and cooperation scenarios.