Details

Autor(en) / Beteiligte

• Gastaca, M.
• Aguero, F.
• Rimola, A.
• Montejo, M.
• Miralles, P.
• Lozano, R.
• Castells, L.
• Abradelo, M.
• Mata, M. de la
• San Juan Rodríguez, F.
• Cordero, E.
• Campo, S. del
• Manzardo, C.
• de Urbina, J.O.
• Pérez, I.
• Rosa, G. de la
• Miro, J. M.

Titel

Liver Retransplantation in HIV‐Infected Patients: A Prospective Cohort Study

Ist Teil von

• American journal of transplantation, 2012-09, Vol.12 (9), p.2465-2476

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Information regarding liver retransplantation in HIV‐infected patients is scant. Data from 14 HIV‐infected patients retransplanted between 2002 and 2011 in Spain (6% retransplantation rate) were analyzed and compared with those from 157 matched HIV‐negative retransplanted patients. In HIV‐infected patients, early (≤30 days) retransplantation was more frequently indicated (57% vs. 29%; p = 0.057), and retransplantation for HCV recurrence was less frequently indicated (7% vs. 37%; p = 0.036). Survival probability after retransplantation in HIV‐positive patients was lower than in HIV‐negative patients, 42% versus 64% at 3 years, although not significantly (p = 0.160). Among HIV‐infected patients, those with undetectable HCV RNA at retransplantation and those with late (>30 days) retransplantation showed better 3‐year survival probability (80% and 67%, respectively), similar to that in their respective HIV‐negative counterparts (72% and 70%). In HIV‐infected and HIV‐negative patients, 3‐year survival probability in those with positive HCV RNA at retransplantation was 22% versus 65% (p = 0.008); in those with early retransplantation, 3‐year survival probability was 25% versus 56% (p = 0.282). HIV infection was controlled with antiretroviral therapy after retransplantation. In conclusion, HIV‐infected patients taken as a whole have unsatisfactory survival after liver retransplantation, although patients with undetectable HCV RNA at retransplantation or undergoing late retransplantation show a more favorable outcome. HIV‐infected liver transplant patients have lower survival after liver retransplantation than matched HIV‐negative liver retransplanted recipients; however, HIV‐infected patients with undetectable HCV RNA at retransplantation or undergoing late retransplantation have a more favorable outcome, similar to that in their HIV‐negative counterparts.