UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 13 von 14
Datensatz exportieren als...
BibTeX
Detection of rare and possibly carcinogenic human papillomavirus genotypes as single infections in invasive cervical cancer
The Journal of pathology, 2012-12, Vol.228 (4), p.534-543
Geraets, Daan
Alemany, Laia
Guimera, Nuria
de Sanjose, Silvia
de Koning, Maurits
Molijn, Anco
Jenkins, David
Bosch, Xavier
Quint, Wim
2012
Details
Autor(en) / Beteiligte
Geraets, Daan
Alemany, Laia
Guimera, Nuria
de Sanjose, Silvia
de Koning, Maurits
Molijn, Anco
Jenkins, David
Bosch, Xavier
Quint, Wim
Titel
Detection of rare and possibly carcinogenic human papillomavirus genotypes as single infections in invasive cervical cancer
Ist Teil von
The Journal of pathology, 2012-12, Vol.228 (4), p.534-543
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The contribution of carcinogenic human papillomavirus (HPV) types to the burden of cervical cancer has been well established. However, the role and contribution of phylogenetically related HPV genotypes and rare variants remains uncertain. In a recent global study of 8977 HPV‐positive invasive cervical carcinomas (ICCs), the genotype remained unidentified in 3.7% by the HPV SPF10 PCR–DEIA–LiPA25 (version 1) algorithm. The 331 ICC specimens with unknown genotype were analysed by a novel sequence methodology, using multiple selected short regions in L1. This demonstrated HPV genotypes that have infrequently or never been detected in ICC, ie HPV26, 30, 61, 67, 68, 69, 73 and 82, and rare variants of HPV16, 18, 26, 30, 34, 39, 56, 67, 68, 69, 82 and 91. These are not identified individually by LiPA25 and only to some extent by other HPV genotyping assays. Most identified genotypes have a close phylogenetic relationship with established carcinogenic HPVs and have been classified as possibly carcinogenic by IARC. Except for HPV85, all genotypes in α‐species 5, 6, 7, 9 and 11 were encountered as single infections in ICCs. These species of established and possibly carcinogenic HPV types form an evolutionary clade. We have shown that the possibly carcinogenic types were detected only in squamous cell carcinomas, which were often keratinizing and diagnosed at a relatively higher mean age (55.3 years) than those associated with established carcinogenic types (50.9 years). The individual frequency of the possibly carcinogenic types in ICCs is low, but together they are associated with 2.25% of the 8338 included ICCs with a single HPV type. This fraction is greater than seven of the established carcinogenic types individually. This study provides evidence that possibly carcinogenic HPV types occur as single infections in invasive cervical cancer, strengthening the circumstantial evidence of a carcinogenic role. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.4065
Titel-ID: cdi_proquest_miscellaneous_1785233390
Format
–
Schlagworte
Age of Onset
,
Biological and medical sciences
,
carcinogenic
,
Carcinoma, Squamous Cell - genetics
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - virology
,
cervical cancer
,
DNA, Viral - analysis
,
DNA, Viral - genetics
,
Female
,
Female genital diseases
,
Genotype
,
Gynecology. Andrology. Obstetrics
,
high-risk
,
HPV26
,
HPV30
,
HPV67
,
HPV73
,
HPV82
,
Human papillomavirus
,
Human papillomavirus 16
,
Human papillomavirus 16 - genetics
,
Human papillomavirus 18 - genetics
,
Humans
,
Infectious diseases
,
Investigative techniques, diagnostic techniques (general aspects)
,
Medical sciences
,
Middle Aged
,
Neoplasm Invasiveness
,
oncogenic
,
Papillomavirus Infections - complications
,
Papillomavirus Infections - genetics
,
Papillomavirus Infections - pathology
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Phylogeny
,
Retrospective Studies
,
Sequence Analysis, DNA - methods
,
Tumors
,
Uterine Cervical Neoplasms - genetics
,
Uterine Cervical Neoplasms - pathology
,
Uterine Cervical Neoplasms - virology
,
Viral diseases
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX