Vaccine, 2015-11, Vol.33 (48), p.6745-6751
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Presentation of peptides from Bacillus anthracis protective antigen on Tobacco Mosaic Virus as an epitope targeted anthrax vaccine
- Ist Teil von
- Vaccine, 2015-11, Vol.33 (48), p.6745-6751
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Highlights • Anthrax peptides were expressed on Tobacco Mosaic Virus as experimental vaccines. • Vaccines showed cross-reactivity to antibodies raised against native toxin. • Immunized mice developed cross-reactive antibodies to native toxin. • Immunization failed to protect mice or cells in vitro against toxin challenge.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2015.10.075Titel-ID: cdi_proquest_miscellaneous_1785232023
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Anthrax, Anthrax Vaccines - administration & dosage, Anthrax Vaccines - genetics, Anthrax Vaccines - immunology, Antibodies, Bacterial - blood, Antibodies, Neutralizing - blood, Antigens, Antigens, Bacterial - genetics, Antigens, Bacterial - immunology, Bacillus anthracis, Bacterial Toxins - genetics, Bacterial Toxins - immunology, Conflicts of interest, Cross Reactions, Drug Carriers, Epitope focused vaccine, Epitopes - genetics, Epitopes - immunology, Female, Genetic Vectors, Goats, Immunoglobulins, Infections, Kinases, Laboratories, Mice, Inbred C57BL, Neutralization, Peptides, Protective antigen, Proteins, Tobacco Mosaic Virus, Tobacco Mosaic Virus - genetics, Toxins, Vaccines, Vaccines, Subunit - administration & dosage, Vaccines, Subunit - genetics, Vaccines, Subunit - immunology, Vaccines, Synthetic - administration & dosage, Vaccines, Synthetic - genetics, Vaccines, Synthetic - immunology, Virgaviridae, Virus nanoparticle vaccine