Details

Autor(en) / Beteiligte

• Johnston, Meredith L.
• Huang, Shao Hui
• Waldron, John N.
• Atenafu, Eshetu G.
• Chan, Kelvin
• Cummings, Bernard J.
• Gilbert, Ralph W.
• Goldstein, David
• Gullane, Patrick J.
• Irish, Jonathan C.
• Perez-Ordonez, Bayardo
• Weinreb, Ilan
• Bayley, Andrew
• Cho, John
• Dawson, Laura A.
• Hope, Andrew
• Ringash, Jolie
• Witterick, Ian J.
• O'Sullivan, Brian
• Kim, John

Titel

Salivary duct carcinoma: Treatment, outcomes, and patterns of failure

Ist Teil von

• Head & neck, 2016-04, Vol.38 (S1), p.E820-E826

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background Salivary duct carcinoma is rare, with distinct morphology and behavior. We reviewed our institutional experience with salivary duct carcinoma, aiming to characterize clinical behavior and treatment outcomes. Methods All salivary duct carcinomas treated curatively between 1999 and 2010 were reviewed. Overall survival (OS), locoregional control, distant control, and patterns of failure were analyzed. Multivariate analysis identified predictors of OS. Results Fifty‐four patients with salivary duct carcinoma (parotid gland = 49; submandibular gland = 5) were included in the analysis. Fifty‐three patients underwent primary surgery, and 48 (89%) received postoperative radiotherapy (RT; median dose = 60 Gy). Median follow‐up was 5.7 years. The 5‐year OS, locoregional control, and distant control were 43%, 70%, and 48%, respectively. Nine local (6 involving facial nerve), 10 regional, and 28 distant failures were identified. Multiple pathologic involved lymph nodes (pN2b/N2c) predicted reduced OS (hazard ratio [HR] = 3.6; p = .02). Conclusion Distant recurrence is common. Presence of pN2b/N2c disease is associated with reduced OS. Local recurrence frequently involves the facial nerves. © 2015 Wiley Periodicals, Inc. Head Neck 38: E820–E826, 2016