FEBS letters, 2016-04, Vol.590 (8), p.1211-1221
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Hepatocyte nuclear factor 1 beta induces transformation and epithelial‐to‐mesenchymal transition
- Ist Teil von
- FEBS letters, 2016-04, Vol.590 (8), p.1211-1221
- Ort / Verlag
- England
- Erscheinungsjahr
- 2016
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12–21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial‐to‐mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1002/1873-3468.12147Titel-ID: cdi_proquest_miscellaneous_1784745283
- Format
- –
- Schlagworte
- Biomarkers - metabolism, Breast Neoplasms - pathology, breast tumor, Cell Line, Tumor, Cell Transformation, Neoplastic - metabolism, Cell Transformation, Neoplastic - pathology, Epithelial-Mesenchymal Transition - genetics, epithelial‐to‐mesenchymal transition, Female, gene amplification, Gene Expression Regulation, hepatocyte nuclear factor 1 beta, Hepatocyte Nuclear Factor 1-beta - genetics, Hepatocyte Nuclear Factor 1-beta - metabolism, Humans, Mutation - genetics, Neoplasm Metastasis, Phenotype, Prognosis, Survival Analysis, three‐dimensional culture, Transcription, Genetic