Details

Autor(en) / Beteiligte

• Lindel, Thomas
• Hochgürtel, Matthias
• Assmann, Michael
• Köck, Matthias

Titel

Synthesis of the Marine Natural Product Nα-(4-Bromopyrrolyl-2-carbonyl)-l-homoarginine, a Putative Biogenetic Precursor of the Pyrrole−Imidazole Alkaloids

Ist Teil von

• Journal of natural products (Washington, D.C.), 2000-11, Vol.63 (11), p.1566-1569

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2000

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Lysine is proposed as an alternative biosynthetic precursor of the pyrrole−imidazole alkaloids frequently found in marine sponges. As a putative key intermediate, the natural product Nα-(4-bromopyrrolyl-2-carbonyl)-l-homoarginine (1) from the sponge Agelas wiedenmayeri was synthesized in the solid phase starting from Fmoc/Pmc-protected l-homoarginine and in solution starting from readily available l-lysine methyl ester.