Details

Autor(en) / Beteiligte

• Yılmaz, Songül
• Özçakar, Z. Birsin
• Taktak, Aysel
• Kiremitçi, Saba
• Ensari, Arzu
• Dinçaslan, Handan
• Yalçınkaya, Fatoş

Titel

Anti-VEGF-related thrombotic microangiopathy in a child presenting with nephrotic syndrome

Ist Teil von

• Pediatric nephrology (Berlin, West), 2016-06, Vol.31 (6), p.1029-1032

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Targeting the vascular endothelial growth factor (VEGF) signaling pathway has become an important approach to current cancer therapy. Anti-VEGF therapy-related renal adverse effects may present as hypertension, non-nephrotic proteinuria, and rarely as nephrotic syndrome (NS) and acute kidney injury. Case-Diagnosis/Treatment In this report, we present a 15-year-old boy who had developed nephrotic syndrome and thrombotic microangiopathy 26 months after administration of anti-VEGF therapy. Treatment was discontinued and nephrotic syndrome remitted spontaneously within 3 months. Conclusions Nephrologists should be aware of the side effects of anti-VEGF therapy. Early diagnosis and prompt management with withdrawal of the agents will result in spontaneous remission.