Bulletin of experimental biology and medicine, 2016, Vol.160 (3), p.336-339
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205
- Ist Teil von
- Bulletin of experimental biology and medicine, 2016, Vol.160 (3), p.336-339
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-016-3164-1Titel-ID: cdi_proquest_miscellaneous_1780527322
- Format
- –
- Schlagworte
- Animals, Anticonvulsants, Anticonvulsants - chemistry, Anticonvulsants - therapeutic use, Benzimidazoles - chemistry, Benzimidazoles - therapeutic use, Biomedical and Life Sciences, Biomedicine, Cell Biology, Drug resistance, Epilepsy, Internal Medicine, Kindling, Neurologic - drug effects, Laboratory Medicine, Male, Mice, Morpholines - chemistry, Morpholines - therapeutic use, Pathology, Pentylenetetrazole - pharmacology, Seizures (Medicine), Seizures - chemically induced, Seizures - drug therapy, Valproic Acid - therapeutic use