Details

Autor(en) / Beteiligte

• Tyurenkov, I. N.
• Perfilova, V. N.
• Karamysheva, V. I.
• Reznikova, L. B.
• Mokrousov, I. S.
• Mikhailova, L .I.
• Berestovitskaya, V. M.
• Vasil’eva, O. S.

Titel

Effect of GABA Derivatives on the Rate of Thrombus Formation, Platelet Aggregation, and Plasma Coagulation Capacity in Rats with Experimental Gestosis

Ist Teil von

• Bulletin of experimental biology and medicine, 2014-12, Vol.158 (2), p.219-221

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2014

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.