Details

Autor(en) / Beteiligte

• Maiborodin, I. V.
• Kuznetsova, I. V.
• Beregovoi, E. A.
• Shevela, A. I.
• Barannik, M. I.
• Maiborodina, V. I.
• Manaev, A. A.

Titel

Reaction of Rat Tissues to Implantation of Lactic Acid-Based Biodegradable Polymer

Ist Teil von

• Bulletin of experimental biology and medicine, 2014-04, Vol.156 (6), p.874-879

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced infl ammatory infi ltration and sclerosis of adjacent tissues. If the implant had no sharp edges, the capsule was thin and the level of infl ammation the minimum. Foreign body giant cells were found in the capsule and near it in all cases. The activity of the infl ammatory process gradually reduced over 6 months. The intensity of infl ammation sharply increased by the 12th month after implantation, when activity of phagocyte enzyme and deformation by the capsule led to fragmentation or liquefaction of polylactide.