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Carboplatin Rechallenge After Hypersensitivity Reactions in Pediatric Patients With Low-Grade Glioma
Pediatric blood & cancer, 2016-01, Vol.63 (1), p.21-26
Shah, Amish C.
Minturn, Jane E.
Li, Yimei
Belasco, Jean B.
Phillips, Peter C.
Kang, Tammy I.
Cole, Kristina A.
Waanders, Angela J.
Pollack, Rosanna
Didomenico, Concetta
Wildes, Cynthia
Fisher, Michael J.
2016
Details
Autor(en) / Beteiligte
Shah, Amish C.
Minturn, Jane E.
Li, Yimei
Belasco, Jean B.
Phillips, Peter C.
Kang, Tammy I.
Cole, Kristina A.
Waanders, Angela J.
Pollack, Rosanna
Didomenico, Concetta
Wildes, Cynthia
Fisher, Michael J.
Titel
Carboplatin Rechallenge After Hypersensitivity Reactions in Pediatric Patients With Low-Grade Glioma
Ist Teil von
Pediatric blood & cancer, 2016-01, Vol.63 (1), p.21-26
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background The high prevalence of carboplatin hypersensitivity reactions (HSR) significantly affects the treatment of pediatric patients with low‐grade glioma (LGG). Rechallenging patients is an option that must balance the risks of repeat allergic reaction to the benefits of retaining an effective anti‐tumor regimen. Procedure We performed a retrospective review of children with LGG treated with carboplatin and vincristine between October 2000 and April 2013, who had a documented HSR to carboplatin. Patients were re‐exposed to carboplatin using either precautionary measures (prolonged infusion time and premedication with H1 antagonists, H2 antagonists, and corticosteroids), a desensitization protocol, or both. Results We report the results of our institutional experience of carboplatin re‐exposure using both premedication with a prolonged infusion time and a desensitization protocol. Overall, 40 of 55 (73%) patients were successfully rechallenged with carboplatin, including 19 of 25 (76%) patients who underwent desensitization. Conclusion Our results demonstrate re‐exposure to be a safe alternative to abandoning carboplatin for patients with a hypersensitivity reaction. We propose a clinical algorithm for treatment. Pediatr Blood Cancer 2015; 9999:1–6 © 2015 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1545-5009
eISSN: 1545-5017
DOI: 10.1002/pbc.25697
Titel-ID: cdi_proquest_miscellaneous_1780502205
Format
–
Schlagworte
Adolescent
,
Adrenal Cortex Hormones - administration & dosage
,
Algorithms
,
allergic reaction
,
Antineoplastic Agents - administration & dosage
,
Antineoplastic Agents - adverse effects
,
Antineoplastic Agents, Phytogenic - administration & dosage
,
carboplatin
,
Carboplatin - administration & dosage
,
Carboplatin - adverse effects
,
Central Nervous System Neoplasms - drug therapy
,
Child
,
Child, Preschool
,
desensitization
,
Desensitization, Psychologic
,
Drug Hypersensitivity - therapy
,
Female
,
Glioma - drug therapy
,
Hematology
,
Histamine H1 Antagonists - administration & dosage
,
Histamine H2 Antagonists - administration & dosage
,
Humans
,
hypersensitivity
,
Infant
,
low-grade glioma
,
Male
,
Neoplasm Grading
,
Oncology
,
Pediatrics
,
rechallenge
,
Retrospective Studies
,
Treatment Outcome
,
Vincristine - administration & dosage
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