Journal of neuro-oncology, 2016-01, Vol.126 (1), p.19-26
2016
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- Autor(en) / Beteiligte
- Titel
- TRIM28 as an independent prognostic marker plays critical roles in glioma progression
- Ist Teil von
- Journal of neuro-oncology, 2016-01, Vol.126 (1), p.19-26
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glioma controls (n = 6). TRIM28 expression was positively correlated with tumor malignancy, and associated with poor overall survival (OS) and progression-free survival (PFS). Notably, TRIM28 expression was negatively correlated with p21 expression in patients with glioblastoma multiforme (GBM). A multivariate analysis that included relevant measures indicated that high TRIM28 expression is an independent prognostic factor for poor OS and PFS in GBM patients. In experiments with cultured glioma cells, down-regulating TRIM28 with shRNA increased p21 expression, and induced cell cycle arrest at the G1 phase. In a xenograft model, down-regulating TRIM28 suppressed tumor growth. These results indicate that over-expression of TRIM28 is associated with poor outcome in glioma patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-594XeISSN: 1573-7373DOI: 10.1007/s11060-015-1897-8Titel-ID: cdi_proquest_miscellaneous_1779880567
- Format
- –
- Schlagworte
- Adult, Animals, Brain - metabolism, Brain - pathology, Brain Neoplasms - diagnosis, Brain Neoplasms - mortality, Cell Cycle Checkpoints - genetics, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21 - genetics, Cyclin-Dependent Kinase Inhibitor p21 - metabolism, Disease Progression, Female, Gene Expression Regulation - genetics, Glioma - diagnosis, Glioma - genetics, Glioma - mortality, Humans, Laboratory Investigation, Male, Medicine, Medicine & Public Health, Mice, Mice, Nude, Middle Aged, Neurology, Oncology, Repressor Proteins - genetics, Repressor Proteins - metabolism, RNA, Small Interfering - genetics, RNA, Small Interfering - metabolism, Survival Analysis, Time Factors, Tripartite Motif-Containing Protein 28, Xenograft Model Antitumor Assays