Details

Autor(en) / Beteiligte

• Ibarluzea, Jesús M.
• Fernández, Mariana F.
• Santa-Marina, Loreto
• Olea-Serrano, Maria F.
• Rivas, Ana M.
• Aurrekoetxea, Juan J.
• Expósito, José
• Lorenzo, Miguel
• Torné, Pablo
• Villalobos, Mercedes
• Pedraza, Vicente
• Sasco, Annie J.
• Olea, Nicolas

Titel

Breast Cancer Risk and the Combined Effect of Environmental Estrogens

Ist Teil von

• Cancer causes & control, 2004-08, Vol.15 (6), p.591-600

Ort / Verlag

Netherlands: Kluwer Academic Publishers

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: The present study aimed to determine whether the combined effects of environmental estrogens measured as the total effective xenoestrogen burden (TEXB-alpha) are a risk factor for breast cancer over and above the risk potentially linked to specific pesticides. Methods: We measured the levels of 16 organochlorine pesticides as well as TEXB in adipose tissue of 198 women at the time of breast cancer diagnosis. These were compared with findings in 260 age and hospital matched control women without breast cancer. Results: The median levels of p,p′-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), aldrin, endosulfan ether and lindane (the pesticides detected in > 40% of the study population) were higher in cases than controls, although the differences did not reach statistical significance. After adjusting for potential confounders, the odds ratio (OR) for breast cancer in women with detectable levels of aldrin was 1.55 (95% confidence interval (CI) 1.00-2.40). Among the postmenopausal women, the OR for aldrin and lindane was 1.84 (95% CI 1.06-3.18) and 1.76 (95% CI 1.04-2.98), respectively. Among cases with body mass index (BMI) below the median (28.6 kg/m2), the OR was 3.42 (95% CI 1.22-9.58) for women in the highest quartile of TEXB-alpha versus those in the lowest. The subgroup of leaner postmenopausal women showed an increased risk (OR: 5.67; 95% CI 1.59-20.21) for those in the highest tertile versus those in the lowest. Conclusions: We found an increased risk for breast cancer in the leaner women, especially in the leaner postmenopausal subgroup, related to the TEXB-alpha. The pesticides aldrin and lindane are also individually associated with risk.