Details

Autor(en) / Beteiligte

• Rezer, João Felipe P
• Souza, Viviane C.G
• Thorstenberg, Maria Luiza P
• Ruchel, Jader B
• Bertoldo, Tatiana M.D
• Zanini, Daniela
• Silveira, Karine L
• Leal, Claudio A.M
• Passos, Daniela F
• Gonçalves, Jamile F
• Abdalla, Fátima H
• Schetinger, Maria Rosa C
• Leal, Daniela B.R

Titel

Effect of antiretroviral therapy in thromboregulation through the hydrolysis of adenine nucleotides in platelets of HIV patients

Ist Teil von

• Biomedicine & pharmacotherapy, 2016-04, Vol.79, p.321-328

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Graphical abstract Group untreated HIV : The figure shows an increase in total cholesterol and these patients an increase in activity of the enzyme E-5′-nucleotidase, indicating that the hydrolysis of nucleotide AMP is high. E-ADA activity is decreased indicating that the nucleoside adenosine (Ado) is being accumulated in the extracellular medium for their cardioprotective effects and vasodilators are acting and/or neutralizing the damage caused by HIV. HIV HAART group: The figure shows an increase in LDL cholesterol and triglycerides. E-NTPDase activity is reduced to ADP hydrolysis indicating that the nucleotide could be in increased levels in the extracellular medium also increasing the platelet aggregation, as an agonist. Since the E-ADA activity is decreased in order to maintain inventory adenosine (Ado) in the extracellular medium which is to play its role cardioprotector against cardiovascular risk generated by increased LDL cholesterol, triglycerides and platelet aggregation.