Otolaryngologic clinics of North America, 2016-04, Vol.49 (2), p.343-380
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland
- Ist Teil von
- Otolaryngologic clinics of North America, 2016-04, Vol.49 (2), p.343-380
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Malignant parotid tumors are heterogeneous and diverse. Accurate diagnosis requires a pathologist familiar with the various histologic subtypes, immunohistochemistry stains, and common translocations. Clinical course varies according to tumor subtype, ranging from indolent, slow-growing adenoid cystic carcinoma to rapidly progressive, possibly fatal, salivary ductal carcinoma. Histologic grade is important in prognosis and therapy. Surgery remains the mainstay of treatment when negative margins can be achieved. Radiation improves locoregional control of tumors with high-risk features. Chemotherapy for parotid tumors can be disappointing. Studies of new targeted therapies have not offered significant benefits.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0030-6665eISSN: 1557-8259DOI: 10.1016/j.otc.2015.11.001Titel-ID: cdi_proquest_miscellaneous_1778711800
- Format
- –
- Schlagworte
- Biopsy, Fine-Needle, Carcinoma, Adenoid Cystic - pathology, Carcinoma, Adenoid Cystic - therapy, Carcinoma, Mucoepidermoid - pathology, Carcinoma, Mucoepidermoid - therapy, Chemotherapy for parotid tumors, Disease Management, Drug Therapy, Genetic translocations of parotid tumors, Humans, Immunohistochemistry, Malignant salivary cancers, Molecular diagnostics, Molecular targeted therapies, Molecular Targeted Therapy, Otolaryngology, Parotid cancer, Parotid Gland - pathology, Parotid Neoplasms - diagnosis, Parotid Neoplasms - therapy, Prognosis, Radiation therapy for parotid cancers, Radiotherapy, Reconstructive Surgical Procedures, Surgery, Surgery for parotid salivary cancer