Chemistry : a European journal, 2013-05, Vol.19 (20), p.6213-6216
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Catalytic Enantioselective Formal Hetero-Diels-Alder Reactions of Enones with Isatins to Give Spirooxindole Tetrahydropyranones
- Ist Teil von
- Chemistry : a European journal, 2013-05, Vol.19 (20), p.6213-6216
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2013
- Quelle
- Wiley(RISS)
- Beschreibungen/Notizen
- Organocatalytic formal hetero‐Diels–Alder reactions of enones with isatins, which gave highly enantiomerically enriched functionalized spirooxindole tetrahydropyranones via an enamine‐based mechanism, were developed. The catalyst systems were identified by a screen of combinations of amines, acids, and additives. With the identified catalyst systems, various spirooxindole tetrahydropyranones were synthesized in high yields with high diastereo‐ and enantioselectivities (see scheme).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0947-6539eISSN: 1521-3765DOI: 10.1002/chem.201300595Titel-ID: cdi_proquest_miscellaneous_1778018480
- Format
- –
- Schlagworte
- Additives, Amines, Amines - chemistry, asymmetric catalysis, Catalysis, Catalysts, Chemistry, cycloaddition, Cycloaddition Reaction, Enrichment, heterocycles, Indoles - chemical synthesis, Indoles - chemistry, Isatin - chemistry, Ketones - chemistry, Molecular Structure, organocatalysis, Pyrones - chemical synthesis, Pyrones - chemistry, Screens, spiro compounds, Spiro Compounds - chemical synthesis, Spiro Compounds - chemistry, Stereoisomerism