Chemistry : a European journal, 2014-05, Vol.20 (20), p.5895-5898
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Hypoiodite-Mediated Cyclopropanation of Alkenes
- Ist Teil von
- Chemistry : a European journal, 2014-05, Vol.20 (20), p.5895-5898
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- An efficient, transition metal‐free procedure for the cyclopropanation of alkenes using malononitrile and the LiI‐tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV‐1 RT inhibitor. An efficient, transition‐metal‐free procedure for the cyclopropanation of alkenes using malononitrile and the LiI/tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV‐1 RT inhibitor (see scheme).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0947-6539eISSN: 1521-3765DOI: 10.1002/chem.201402372Titel-ID: cdi_proquest_miscellaneous_1778010109
- Format
- –
- Schlagworte
- Alkenes, Alkenes - chemical synthesis, Alkenes - chemistry, Anti-HIV Agents - chemical synthesis, Anti-HIV Agents - chemistry, Chemistry, Cyclization, cyclopropanation reactions, Cyclopropanes - chemical synthesis, Cyclopropanes - chemistry, hypoiodous acid, Inhibitors, iodine, Iodine - chemistry, Iodine Compounds - chemical synthesis, Iodine Compounds - chemistry, Malononitrile, Methodology, oxidation, Oxidation-Reduction, Reaction mechanisms, Reverse Transcriptase Inhibitors - chemical synthesis, Reverse Transcriptase Inhibitors - chemistry, small ring systems, Synthesis, Utilities