Details

Autor(en) / Beteiligte

• Orlov, Alexey A.
• Chistov, Alexey A.
• Kozlovskaya, Liubov I.
• Ustinov, Alexey V.
• Korshun, Vladimir A.
• Karganova, Galina G.
• Osolodkin, Dmitry I.

Titel

Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

Ist Teil von

• MedChemComm, 2016-03, Vol.7 (3), p.495-499

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl uracil nucleosides with bulky aryl groups, appeared to have considerable activity against tick-borne encephalitis virus (TBEV) in cell culture. The rigid ethynyl linker and perylene residue are essential structural prerequisites for high activity, giving EC 50 values of 18 and 24 nM for 5-(perylen-3-yl)ethynyl- arabino -uridine and 5-(perylen-3-yl)ethynyl-2′- deoxy -uridine, respectively, upon simultaneous mixing of the compounds, cells and virus.